Decrease in the level and mRNA expression of LH-RH and EGF receptors after treatment with LH-RH antagonist cetrorelix in DU-145 prostate tumor xenografts in nude mice.
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منابع مشابه
Luteinizing hormone-releasing hormone (LH-RH) antagonist Cetrorelix down-regulates the mRNA expression of pituitary receptors for LH-RH by counteracting the stimulatory effect of endogenous LH-RH.
The mechanisms through which LH-RH antagonists suppress gonadotroph functions and LH-RH receptor (LH-RH-R) production are incompletely understood. To elucidate these mechanisms, we investigated the effects of Cetrorelix on the mRNA expression of pituitary LH-RH-R and luteinizing hormone (LH) secretion in three experimental systems with different pituitary LH-RH environments. Ovariectomy induced...
متن کاملDown-regulation of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) in rats by LH-RH antagonist Cetrorelix.
Antagonists of luteinizing hormone-releasing hormone (LH-RH), unlike the LH-RH agonists, suppress gonadotropins and sex steroid secretion immediately after administration, without initial stimulatory effects. [Ac-D-Nal(2)1,D-Ph(4Cl)2,D-Pal(3)3,D-Cit6,D-Ala10]LH-R H (SB-75; Cetrorelix) is a modern, potent antagonistic analog of LH-RH. In this study, the binding characteristics of receptors for L...
متن کاملOvulation and Endocrine Response after Lh-rh in Domestic Animals
cows 2 weeks after parturition and in diestrous and proestrous heifers. Serum LH concentrations increased after LH-RH treatment and the greatest response was observed in cows with ovarian follicular cysts. Serum progesterone concentrations were increased at 6 hours after LH-RH in animals which had functional luteal tissue in the ovaries but serum estradiol and estrone were unchanged. Ovarian fo...
متن کاملEffect of steroids in combination with LH-RH on the release of LH and FSH in LH-RH-primed immature male rat.
LH and FSH release of immature male rats was remarkedably enhanced by LH-RH if primed with LH-RH one hour before. The effect of exogenous steroids on the action of the second LH-RH was investigated. C-18, C-19 and C-21 steroids in different doses were tested. Blood samples were collected from the jugular vein immediately before and 30 min after the second LH-RH injection. Serum LH and FSH were ...
متن کاملPlasma LH concentrations after single or double injections of synthetic LH-RH in dairy cows.
Milked Friesian dairy cows were given 1 or 2 i.v. injections of synthetic LH-RH. The second of 2 injections of LH-RH given 1.5 h apart induced a significantly greater release of LH than did the first. The response to this injection was also significantly greater than that caused by injections given 6 h apart. There was no significant difference between the LH responses to the two injections giv...
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ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 1998
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.13.3.429